METHOTREXATE–Reincarnation of an Old Drug

Methotrexate (MTX) is by far the most popular oral agent used by dermatologists today for psoriasis and has been so for the last 40 years.  Its epitaph was nearly written after the more potent biologic immunomodulators such as Enbrel and Humira were predicted to render MTX obsolete.  Now it appears that … Continue reading

Psoriasis Treatments

Psoriasis is a heavy burden for both the physical and economic health of the nation, affecting about 7.5 million Americans.  The annual cost for treating psoriasis in the U.S. in 2008 was $11.25 billion.  The average cost per patient, estimated at $5500 per year, is much higher for more severe … Continue reading

Cyclosporine, Psoriasis, and Grapefruit Juice

Cyclosporine (CS), a potent immunosuppressive peptide, was discovered by Sandoz in 1975.  Clinical testing showed that it was very effective for preventing rejection of life-saving organ transplants such as kidney, heart, liver, and bone marrow.  Investigators also noted the impressive ability of CS to clear up any psoriasis on the … Continue reading