METHOTREXATE–Reincarnation of an Old Drug

Methotrexate (MTX) is by far the most popular oral agent used by dermatologists today for psoriasis and has been so for the last 40 years.  Its epitaph was nearly written after the more potent biologic immunomodulators such as Enbrel and Humira were predicted to render MTX obsolete.  Now it appears that … Continue reading

Bullous Pemphigoid: Please Don’t Confuse It With Pemphigus Vulgaris

Bullous Pemphigoid (BP) is an uncommon autoimmune skin disease which leads to a very

itchy hive-like rash and blisters.  The blisters can occur anywhere on the body, but the underarms, arms, groins, and lower legs seem more commonly affected in my experience, sometimes limited to these areas alone.  The mucous … Continue reading

Psoriasis Treatments

Psoriasis is a heavy burden for both the physical and economic health of the nation, affecting about 7.5 million Americans.  The annual cost for treating psoriasis in the U.S. in 2008 was $11.25 billion.  The average cost per patient, estimated at $5500 per year, is much higher for more severe … Continue reading

Vitamin D Analogues for Psoriasis

Vitamin D analogues are popular for the local treatment of psoriasis.  The first compound approved in the U.S. was calcipotriene (brand name Dovonex) available as cream, ointment, and lotion (for the scalp) for twice daily application.  It was modestly … Continue reading